Glaucoma Research

1. In a study of open angle glaucoma patients who received 150mg of Alpha Lipoic Acid each day, 45-47% of the eyes had enhancement of colour visual fields and visual sensitivity when compared to controls using only topical medical therapy. More advanced cases had an even better response compared to their controls. Filina, et al., Vestn Oftalmol 1995 Oct- Dec;111(4):6-8

2. Pre-treatment with Alpha Lipoic acid has been found to reduce neuronal damage from excitotoxic damage from cyanide, glutamate and iron ions, demonstrating a strong neuroprotective effect for this substance in nerve tissue. It may be useful in treating glaucoma. (Ed. Note: Recent evidence points to the importance of neuroprotection against glutamate in glaucoma patients, with many medications now heavily promoting this property!) J Cereb Blood Flow Metab 1995 Jul;15(4):624-30 Altern Med Rev 1998 Aug;3(4):308-11 (Other ALA/Neuroprotective Studies)

3. The eyes of open angle glaucoma patients were found to have significantly lower vitamin C levels, as well as higher levels of lipic peroxidation by-products compared to normals. Aleksidze, et al. Oftalmol Zh 1989;(2):114-6

4. Patients suffering from open angle glaucoma and normal-tension glaucoma that were given magnesium twice daily showed improvement of the visual field and reduced peripheral vasospasms (which can cause glaucoma, stroke and heart attack) after four weeks of treatment. Gaspar, et al; Ophthalmologica 1995;209(1):11-3

5. Glaucoma patients treated with vitamin B12 for over 5 years demonstrated better visual acuity and better overall control of their disease. Glacome, 1992; Nippon Ganka Kiyo. 1965 Mar.; Oftalmol Zh. 1965; 20(6); Klin Oczna 1974 Nov;44(11):1183-7

6. Besides beta-carotene, other Carotenoids found in dark green leafy vegetables appear to be much more essential to the health of the eye. Several studies have shown that Lutein and Zeaxanthin supplements may slow vision loss in glaucoma, and in some cases improve eyesight. Science News, Volume 146.

7. Anthocyanosides, compounds found in the herb bilberry, were shown to markedly improve vascular resistance of the capillary wall in the ciliary body of the eye (the source of excess fluid production). Boll. Ocul. 65 789-95, 1986

8. Chronic open angle glaucoma patients had a statistically significant lower thiamine blood level than controls along with poor absorption of that nutrient. Asregadoo, Ann Ophthalmol 1979 Jul;11(7):1095-1100

9. Lipoic acid may be useful in the treatment of glaucoma and may help prevent ischemic optic nerve damage. Altern Med Rev 1998 Aug;3(4):308-11

10. The scientific literature supports recommending Lipoic acid in complex with vitamins B1, B2, B5, B6 (pyridoxal phosphate), and vitamin C to glaucoma patients. Filina, AA & Sporova, NA. Vestn Oftalmol 1991 May-Jun;107(3):19-21

11. Vascular obstruction and hindrance of the blood flow and impaired nutrition of neuronal tissue might be the primary causes of glaucoma. Sonnsjo & Krakau, Acta Ophthalmol (Copenh) 1993 Aug;71(4):433-44

12. Ginkgo Biloba is a potentially important agent in the treatment of glaucoma. It improves central and peripheral blood flow, reduces vasospasm, reduces serum viscosity, has antioxidant activity, platelet activating factor inhibitory activity, and inhibits apoptosis and excitotoxicity – all factors in preventing glaucoma vision loss. (Ed. Note: magnesium also has been shown to decrease peripheral vasospasms, improving blood flow and is neuroprotective, as well.) Ritch R. Med Hypotheses 2000 Feb;54(2):221-35

13. The fatty acid DHA (abundant in fish oil), along with B Complex and vitamin E were shown to be helpful in preventing or delaying vision loss associated with glaucoma. Cellini M, et al., Acta Ophthalmol Scand Suppl 1998;(227):41

14. Ginkgo Biloba extract (40mg, three times daily), increased diastolic blood flow by 23% in the ophthalmic artery in glaucoma patients and may be helpful in protecting the optic nerve from further damage and subsequent visual field loss. Chung HS, et al. J Ocul Pharmacol Ther 1999 Jun;15(3):233-40 (NB: Ginkgo must be used with caution by those taking Coumadin, as it may increase its effect – possibly eliminating the need for it?)

15. Besides Alpha Lipoic Acid, other nutrients that are neuroprotective include vitamin E, Ginkgo Biloba, pycnogenol (from grape seed extract or pine bark), and flavonoids. Kobayashi MS, et al. Free Radic Res 2000 Feb;32(2):115-24